Drugs that interact with finasteride, which is the main male hormone receptor drugs bind to. I believe that the two main interactions described are related, and would explain why this study found no difference in the incidence of sexual changes among those who responded to finasteride versus those who did not respond, but in those who responded and well but had lower than normal levels. A new paper in the journal Endocrinology addresses safety of finasteride in men. this paper, published by the Endocrine Society, Dr. Alan E. Thakkar, a professor of endocrinology from the Oregon Health and Science University in Portland, researcher Dr. M. Mary-Lynn Wacker, summarize results from the placebo-controlled trial that demonstrated finasteride does not impair sperm production in the laboratory. Here's the abstract from that paper: "No adverse effects of finasteride on fertility were noted in 1137 men from the Propecia [Nexavar] trials — a placebo-controlled study and the largest long-term clinical trial of finasteride. Sperm concentration and motility, as measured by motility assay, showed no significant decrease following finasteride cessation. We have found no evidence to indicate that use of finasteride may impair male fertility or that treatment discontinuation is associated with an altered outcome. Finasteride is approved by the U.S. Food and Drug Administration for the treatment of benign prostatic hyperplasia; it is also used off-label to treat or prevent premature prostate development in men with symptomatic benign prostatic hyperplasia. Thus, finasteride usage in male patients with benign prostatic hyperplasia is not a contraindication to finasteride use for male sexual dysfunction." Read what Thakkar and Wacker have to say here: https://endocrine.org/sites/endocrine.org/files/articles/2014/03/jpr_20131114_finasteride.pdf Here's what our good friends at ProConaTix emailed me: "Finasteride, a chemical used to block the male sex hormone, is used to treat benign prostatic hyperplasia (BPH). This study is part of a larger analysis clinical data that has been published with the Propecia (Viagra) product that showed a lower incidence of prostate cancer among those who received Viagra versus placebo. Since was approved as a treatment for BPH in 1998, the FDA Can you buy terbinafine hydrochloride cream over the counter approved a new antiandrogen — finasteride for the same treatment. Our research team at ProConaTix recently published the results of 2 studies that demonstrate a possible link between BPH and finasteride use. The first study was designed to determine if finasteride use affects the development of certain genetic mutations that may decrease a man's ability to produce sperm. The results showed that finasteride's ability to inhibit mutations did indeed affect sperm production in the laboratory. For men taking finasteride in the early trials who received no previous antiandrogens, these mutations were less likely to be present in sperm. This indicates that finasteride may affect sperm production in those with normal DNA but a genetic mutation that results in low sperm production." One interesting aspect of this is that might lend support to the theory that Finasteride does not damage certain prostate glands but only the prostate. This was discovered when a Finnish study, American online pharmacy with prescription which attempted to replicate the original results published by Pfizer, reported not a significant difference in the occurrence of "significantly reduced levels prostate specific antigen" in the Finasteride treatment group when compared to the placebo.
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